Sachem is a title given to a Native American paramount chief.
Sachem may also refer to:
- Sachem (butterfly), another name for the skipper butterfly Atalopedes campestris
- The Sachem, a Canadian newspaper
- The Sachems, a secret society at Columbia University
- SS Sachem, ships with the name
- USS Sachem, US Navy vessels with the name
- A leader of Tammany Hall